Ovarian rejuvenation is a fertility treatment that uses Platelet-Rich Plasma (PRP) to stimulate the ovaries, improve female fertility, and boost the chance of pregnancy either naturally or through IVF.

PRP is a concentrated solution of growth factors and cytokines taken from a sample of your own blood. When introduced into the ovaries and uterine cavity, PRP helps repair damaged tissue in the ovaries, increases follicle growth, stimulates the production of new eggs, and ultimately improves egg quality and quantity to increase your chances of pregnancy.

In sum, ovarian rejuvenation therapy with PRP stimulates cellular rejuvenation and blood flow, naturally and effectively enhancing your own fertility.

Platelet-Rich Plasma (PRP) is produced by spinning a sample of your blood in a centrifuge so that it separates the plasma from the red and white blood cells. The platelets-rich plasma in your body helps blood clot when there is an injury. Additionally, the cytokines and growth factors that are in the platelets can help repair injuries and wounds and encourage healing.

Different types of PRP products have been used recently to heal injuries. For example, PRP injections have been used to treat knee osteoarthritis, various sports injuries (i.e. ligament tears and joint sprains), and even hair loss. We at New Hope Fertility Center, use PRP technology to stimulate your ovaries in order to induce follicle growth and egg production for fertilization and thus increase your chance of pregnancy.

There are 2 techniques by which you can receive the ovarian rejuvenation treatment using PRP: (1) Ovarian Injection or (2) Uterine Infusion. Your fertility doctor will perform an assessment and decide on the number and location of the injections, depending on your individual condition and the method that fits you best. Moreover, the cost of treatment will vary depending on whether Uterine PRP or Ovarian PRP is administered.

This procedure is performed in our surgical suite as an outpatient treatment. To ensure that you do not experience discomfort, you will be provided with a pain management option of a local anesthetic or intravenous (IV) anesthesia. If IV anesthesia is chosen, a Board-Certified Anesthesiologist will administer the medication during the procedure.

Then, the physician performing the procedure will use a trans-vaginal approach to inject the PRP in the ovaries. The procedure lasts approximately 15-20 minutes. Thereafter, you will be brought to a recovery area where you will be monitored until you recover for discharge, approximately one (1) hour. Upon discharge, it is advised that you have a companion to accompany you home for safety.

This procedure is performed in an exam room as an outpatient treatment. You will be asked to assume the dorsal-lithotomy position and the provider will infuse PRP into the uterine cavity while you remain on the exam table. The procedure takes approximately 15 minutes and there is no post recovery needed.

Ovarian rejuvenation using PRP can be beneficial for women who are struggling to conceive due to very low ovarian reserve (low AMH), as well as women who experience early menopause, those who have poor quality and/or quantity of eggs, or those who have had poor response to IVF. Additionally, ovarian rejuvenation treatment can help women who experienced failed embryo transfer, women with recurrent implantation failure, or women who have thin endometrial lining.

In fact, several recent studies found that PRP for Fertility has led to:

• Higher AMH values and higher antral follicles, enabling the retrieval of more mature oocytes during IVF
• Spontaneous resumption of menstrual cycle for early menopause patients
• Improvement in IVF cycle outcome, especially among poor IVF responders
• Higher number of retrieved oocytes during IVF, leading to better quality embryos

This treatment option involves 3 simple steps:

1. A phlebotomist obtains a blood sample from your forearm.
2. The blood sample is placed in a centrifuge for 10-15 minutes to separate the plasma (PRP) from the red and white blood cells.
3. The PRP is transferred to a syringe and injected into the ovaries or uterus in a minimally invasive procedure.

After your procedure, your doctor will advise you to start monitoring (blood work and ultrasound) once a week. Results have been seen 2 to 8 weeks post procedure.