PGS – Preimplantation Genetic Screening – is the testing of an embryo’s overall chromosomal normality prior to being transferred to the patient’s uterus in conjunction with In Vitro Fertilization (IVF). Specifically, PGS identifies the most suitable and healthiest embryo to transfer by detecting chromosomal deficiencies – aneuploidy – an extra or missing chromosome.

PGS Increases Pregnancy Success Rates

New studies show that PGS dramatically increases a woman’s chance of conception. This is because her doctor has the skill and expertise to identify the most suitable and healthiest embryo(s) to transfer. At the New Hope fertility clinic in New York City, embryo biopsy and screening can increase a patient’s chance of a successful pregnancy by up to 30 percent.

PGS vs. PGD

PGS differs from Preimplantation Genetic Diagnosis (PGD) because the procedure does not diagnose an inherited genetic defect in the embryo. PGS searches for aneuploidy – extra or missing chromosomes.

In comparison, PGD diagnoses genetic defects such as:

  • Cystic Fibrosis
  • Tay-Sachs
  • Hemophilia
  • Sickle Cell Anemia

Candidates for Preimplantation Genetic Screening (PGS)

Because advanced maternal age (over 35) adversely affects the quality of a woman’s eggs (oocytes) resulting in chromosomal abnormalities, New Hope Fertility Center recommends PGS in conjunction with IVF to all patients over the age of 35.

In an ideal world, our fertility doctors would recommend PGS for every IVF patient. The pros of PGS are that you learn a lot about the health of your embryo and then can make completely informed decisions about your fertility treatment. The cons of PGS are cost and a 1.5 percent error rate. PGS finding are not infallible.

Other Candidates for PGS

  • Women that have a history of recurrent miscarriages (2 or more)
  • Women that have failed IVF cycles
  • Gender Selection – Family Balancing

PGS Detects Low Quality Embryos

By extracting a cell from an embryo and analyzing it, poor quality embryos are detected. Biopsy of this cell will not damage the embryo.

Low quality embryos result in:

  • Low pregnancy success rates
  • High miscarriage rates
  • High chance for birth defects

LEARN MORE ABOUT PREIMPLANTATION GENETIC SCREENING

(click the links below for more infertility information)

Next Generation Sequencing (NGS)

New Hope Fertility Center in New York is committed to providing the latest and best fertility technology.  NGS – Next Generation Sequencing – is a new method of PGS. NGS is the latest genetic screening test for primary candidates undergoing IVF. NGS is used for comprehensive chromosome testing of embryos created through IVF. NGS is on the horizon to replacing PGS because of the procedure’s lower cost and reduced errors.

NGS allows embryologists to screen for defects on the chromosomal level with higher accuracy and more detail than ever before. PGS results are comprehensive and a higher resolution than any other genetic testing method because it detects more translocations.

NGS may be run as a standalone test – or in conjunction with PGS – at a faster completion rate. NGS also detects mosaicism – when the embryo’s cells exhibit different chromosomal content.

Primary Benefits of NGS

  • Reduce the number of miscarriages
  • Reduce the number of IVF cycles
  • Reduce the risk of multiple pregnancy with a single embryo transfer
  • Increase ongoing pregnancy rates
  • Increase live births

Importance of NGS

As a woman reaches an advanced maternal age (35 and older), there is a greater chance that her low quality eggs will create chromosomally abnormal embryos. The primary goal of NGS is to transfer embryos that have been found to have a normal chromosomal number – euploid.

Embryo morphology – how the embryo looks – alone as a means of selection for transfer is not the best tool. It is best to couple PGS with NGS to eliminate the chance of good looking embryos being abnormal.

genetic screening nyc

NGS (Next Generation Sequencing)

Next Generation Sequencing (NGS) is the latest genetic screening test for fertility patients and is a form of PGS. It allows embryologists to screen for defects on the chromosomal level with higher accuracy and more detail than ever before. Results are comprehensive and a higher resolution than any other test and will detect more translocations. It may be run as a stand alone test or in conjunction with PGD and is faster to complete. NGS can also detect mosaicism which is when the embryo’s cells exhibit different chromosomal content.

  • Reduce the number of miscarriages
  • Reduce the number of IVF cycles
  • Reduce the risk of multiple pregnancy with single embryo transfer
  • Increased ongoing pregnancy rates and live birth rates

GIVE YOURSELF THE EDGE WITH PGS/NGS

ongoing-pregnancy-rate

Why is NGS Important?

generation sequencing nyc fertility center

  • As maternal age increases, more embryos are chromosomally abnormal
  • The main goal of NGS is to transfer embryos back to the uterus that have been found to be euploid (having normal chromosomal numbers)
  • Embryo morphology (how the embryo looks) alone as a means of embryo selection for transfer is not the best tool. It is best to be coupled with NGS. We have found that even the best looking embryos can be genetically abnormal.

Talk to your physician and discuss how you may have this test ordered.

  

LEARN MORE ABOUT NEXT GENERATION SEQUENCING

(click the links below for more infertility information)