PGS (Preimplantation Genetic Screening)

Preimplantation Genetic Screening (PGS) is very similar to PGD, however, instead of diagnosing a known genetic defect, PGS will screen and identify unknown chromosomal abnormalities in an embryo. Since age affects the quality of eggs (oocytes) as well as increases the chance of genetic abnormality, we recommend PGS to patients over the age of 35. Additionally, this test is well suited for patients who have a history of miscarriages, multiple failed IVF cycles, or family balancing. New studies are showing that PGS may dramatically increase your chance of pregnancy by allowing Fertility Specialist to identify the most suitable and healthiest embryo to transfer. PGS will not test for inherited genetic defects, like Cystic Fibrosis, but more specifically, deficiencies on chromosomes known as aneuploidy (an extra or missing chromosome).

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NGS (Next Generation Sequencing)

Next Generation Sequencing (NGS) is the latest genetic screening test for fertility patients and is a form of PGS. It allows embryologists to screen for defects on the chromosomal level with higher accuracy and more detail than ever before. Results are comprehensive and a higher resolution than any other test and will detect more translocations. It may be run as a stand alone test or in conjunction with PGD and is faster to complete. NGS can also detect mosaicism which is when the embryo’s cells exhibit different chromosomal content.

  • Reduce the number of miscarriages
  • Reduce the number of IVF cycles
  • Reduce the risk of multiple pregnancy with single embryo transfer
  • Increased ongoing pregnancy rates and live birth rates



Why is NGS Important?

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  • As maternal age increases, more embryos are chromosomally abnormal
  • The main goal of NGS is to transfer embryos back to the uterus that have been found to be euploid (having normal chromosomal numbers)
  • Embryo morphology (how the embryo looks) alone as a means of embryo selection for transfer is not the best tool. It is best to be coupled with NGS. We have found that even the best looking embryos can be genetically abnormal.

Talk to your physician and discuss how you may have this test ordered.