For women facing the challenge of low ovarian reserve, the journey to conception can feel overwhelming and emotionally exhausting. While traditional fertility treatments remain an important option, some are also exploring innovative approaches like PRP that may offer new possibilities and renewed hope for family-building.

Platelet-rich plasma (PRP) ovarian treatment has emerged as a promising therapy option that aims to rejuvenate ovarian tissue and potentially improve fertility outcomes. Early clinical studies suggest that PRP for Fertility may offer new possibilities for women whose ovarian function has declined due to age, medical treatments, or other factors.

Understanding the science, safety profile, and realistic expectations surrounding PRP ovarian reserve treatment is essential for making informed decisions about your fertility journey.

Understanding PRP for Fertility

Platelet-Rich Plasma (PRP) is a concentrated solution derived from a patient’s own blood that contains high levels of growth factors and healing proteins. The preparation process involves drawing a small amount of blood, typically 30-60 milliliters, which is then processed through centrifugation to separate and concentrate the platelets.

During centrifugation, blood components are separated by density, allowing medical professionals to extract the plasma layer rich in platelets, growth factors, and cytokines. This concentrated solution contains significantly higher levels of healing factors compared to regular blood plasma.

For ovarian rejuvenation, the PRP solution is carefully injected directly into the ovarian tissue using ultrasound guidance. This minimally invasive procedure is typically performed as an outpatient treatment, requiring no general anesthesia and minimal recovery time.

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How Does PRP Address Low Ovarian Reserve?

The mechanism behind PRP ovarian treatment centers on the regenerative properties of concentrated growth factors and cytokines found in platelets. These bioactive compounds are believed to stimulate cellular repair, promote angiogenesis (new blood vessel formation), and activate dormant ovarian follicles that may have been inactive.

Growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF) may help rejuvenate ovarian tissue by:

  • Activating dormant follicles: Potentially awakening primordial follicles that have remained inactive
  • Improving oocyte quality: Enhancing the cellular environment for healthier egg development
  • Increasing ovarian blood flow: Promoting better nutrient delivery to developing follicles
  • Reducing oxidative stress: Providing antioxidant effects that may protect ovarian tissue

Clinical Evidence: What Studies Show

Current research on PRP ovarian treatment presents optimistic findings, though the field requires more extensive investigation. A 2025 critical review published in PMC examined multiple clinical trials and found that PRP may offer measurable improvements in several key fertility parameters.

Hormonal Improvements:

  • AMH levels increased by 15-25% in some patients within 2-3 months post-treatment
  • Follicle-stimulating hormone (FSH) levels showed improvements in approximately 30% of participants
  • Estradiol production demonstrated modest increases in select studies

Ovarian Function Markers:

  • Antral follicle count improvements reported in 40-60% of treated patients
  • Enhanced ovarian response during subsequent IVF stimulation cycles
  • Improved egg retrieval numbers in some follow-up IVF procedures

A comparative study published in Nature (May 2025) examined single versus double PRP injections, finding that multiple treatments may provide more sustained benefits. The most effective treatment protocol is still being studied.

Research from Aging-US (March 2022) specifically examined IVF outcomes following PRP treatment, reporting improved embryo quality scores and slightly higher pregnancy rates compared to control groups.

PRP Therapy vs Traditional Fertility Solutions

Understanding how PRP compares to established fertility treatments helps set realistic expectations and guide treatment decisions. Common approaches for low ovarian reserve include hormone-based medications, IVF with higher stimulation protocols, and in some cases, the use of donor eggs.

PRP Advantages:

  • Uses the patient’s own biological materials, minimizing rejection risk
  • Minimally invasive outpatient procedure
  • May improve the underlying ovarian environment rather than just working around diminished function
  • Potential to enhance outcomes of subsequent fertility treatments
  • Lower immediate side effect profile compared to hormonal medications

Other PRP Considerations:

  • PRP for fertility is still relatively new, so long-term studies are ongoing
  • Outcomes can vary depending on the individual
  • Research has not yet confirmed a direct link to higher pregnancy rates
  • More than one session may sometimes be recommended
  • Because it is an emerging therapy, most insurance providers do not yet cover the cost

Notably, PRP is generally considered a complementary therapy, often used alongside IVF or other fertility treatments to potentially enhance their effectiveness.

Take the Next Step Toward Your Family Goals

If you are struggling with low ovarian reserve and wondering whether PRP ovarian treatment might be right for your situation, the fertility specialists at New Hope Fertility Center are here to help you explore all available options.

Our board-certified reproductive endocrinologists stay current with the latest advances in fertility medicine, including emerging therapies like platelet-rich plasma ovarian rejuvenation. We understand that each patient’s experience is unique, and we are committed to providing personalized treatment plans that align with your specific needs and goals.

Schedule a consultation today to discuss whether PRP therapy could be a valuable addition to your fertility treatment plan. Together, we can evaluate your individual situation and help you make informed decisions about innovative approaches that may bring you closer to achieving your dream of parenthood.

FAQs: PRP Ovarian Treatment

Does PRP therapy help with low ovarian reserve?

Early clinical studies suggest PRP may improve markers of ovarian function, including Anti-Müllerian Hormone (AMH) levels and antral follicle count (AFC).

Some women experience improvements in hormone levels and egg quality following PRP treatment, but individual results vary. The therapy shows promise in activating dormant follicles and improving oocyte development in preliminary studies.

PRP is not expected to fully restore ovarian function to youthful levels. However, early studies suggest it may help support existing ovarian activity, with potential benefits for follicle growth and hormone production.

PRP is typically used as an adjunct to IVF rather than a replacement. While IVF directly addresses conception through assisted reproduction, PRP aims to improve the underlying ovarian environment that could enhance IVF outcomes.

PRP appears to have minimal adverse effects since it uses the patient’s own blood components. Reported side effects are typically mild, including temporary discomfort at the injection site.

We provide transparent pricing for our PRP treatments. Contact us to learn more about costs and available options.

New Hope Editorial Team

Written by the New Hope Editorial Team

As experts in IVF and Assisted Reproductive Technologies, we are committed to educating and empowering people on their fertility journey with accurate information and compassionate care.