Zhuo Lu, Ph.D

Lab Manager

Senior Embryologist

 Dr. Zhuo Lu received his Bachelor’s Degree in Biotechnology from Northeast Agricultural University in China in 2002 and his Ph.D. in Developmental Biology from the Institute of Zoology at the Chinese Academy of Sciences in 2011.  He has published over a dozen scientific papers including a seminal investigation published in Nature in which he personally produced the first viable iPS mouse through tetraploid complementation that proved iPS cells have the same developmental potential as ES cells. This study was reported by dozens of media outlets and was hailed by Time Magazine as one of the top 10 medical breakthroughs of 2009.  Dr. Lu contributes to the ongoing research at New Hope Fertility Center, specifically in developing and improving nuclear transfer techniques. With his efforts, the NHFC research team achieved the great breakthrough on mitochondrial replacement therapy (MRT).

Dr. Lu currently holds the position of Senior Embryologist at New Hope Fertility Center since 2011. He has over 10 years of experience with micromanipulation and insemination techniques with a highly successful fertilization and blastocyst rate. And he is also highly skilled in blastomere and trophectoderm biopsy with thousands of cases performed at New Hope Fertility Center. Dr. Lu is well respected and trusted by peers and patients alike.

Message from Dr. Zhuo Lu

"All NHFC embryologist undergo rigorous training in order to provide our patients with the utmost care, knowledge, and experience of your gametes and embryos."

Publications

Publications

  1. Zhao XY*, Li W*, Lv Z*, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F, Zhou Q. (* contributed equally to the work)

iPS cells produce viable mice through tetraploid complementation.

Nature. 2009 Sep 3;461(7260):86-90.

  1. Zhao XY*, Li W*, Lv Z*, Liu L, Tong M, Hai T, Hao J, Guo CL, Wang X, Wang L, Zeng F, Zhou Q. (* contributed equally to the work)

Efficient and rapid generation of induced pluripotent stem cells using an alternative culture medium.

Cell Res. 2010 Mar;20(3):383-6.

  1. Zhao XY*, Li W*, Lv Z*, Liu L, Tong M, Hai T, Hao J, Wang X, Wang L, Zeng F, Zhou Q. Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cells. Stem Cell Rev. 2010 Sep;6(3):390-7. (* contributed equally to the work)
  2. Tong M*, Lv Z*, Liu L*, Zhu H*, Zheng QY, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH, Zhou Q.

Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis.

Cell Res. 2011 Nov;21(11):1634-7. (* contributed equally to the work)

  1. Wu Y*, Lv Z*, Yang Y*, Dong G, Yu Y, Cui Y, Tong M, Wang L, Zhou Z, Zhu H, Zhou Q, Sha J.

Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice.

Cell Mol Life Sci. 2013 Sep 14.

  1. Zeng Y*, Lv Z*, Gu L, Wang L, Zhou Z, Zhu H, Zhou Q, Sha J. (* contributed equally to the work)

Preimplantation genetic diagnosis (PGD) influences adrenal development and response to cold stress in resulting mice.

Cell Tissue Res. 2013 Oct 9

  1. Z Lu, H Liu, A Chavez-Badiola, M Konstantinidis, S Munné, J Zhang

The impact of human oocyte reconstruction using meiosis II spindle transfer on the pre-implantation embryonic development

Fertility and Sterility 104 (3), e305. 2015

  1. Yu Y, Wu J, Fan Y, Lv Z, Guo X, Zhao C, Zhou R, Zhang Z, Wang F, Xiao M, Chen L, Zhu H, Chen W, Lin M, Liu J, Zhou Z, Wang L, Huo R, Zhou Q, Sha J.

Evaluation of blastomere biopsy using a mouse model indicates the potential high risk of neurodegenerative disorders in the offspring.

Mol Cell Proteomics. 2009 Jul;8(7):1490-500.

  1. Ma M, Zhou L, Guo X, Lv Z, Yu Y, Ding C, Zhang P, Bi Y, Xie J, Wang L, Lin M, Zhou Z, Huo R, Sha J, Zhou Q.

Decreased cofilin1 expression is important for compaction during early mouse embryo development.

Biochim Biophys Acta. 2009 Dec;1793(12):1804-10.

  1. Zhao XY, Lv Z, Li W, Zeng F, Zhou Q.

Production of mice using iPS cells and tetraploid complementation.

Nat Protoc. 2010;5(5):963-71.

  1. Liu L, Luo GZ, Yang W, Zhao X, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ, Zhou Q

Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells.

J Biol Chem. 2010 Jun 18;285(25):19483-90

  1. Zhao X, Lv Z, Liu L, Wang L, Tong M, Zhou Q.

Derivation of embryonic stem cells from Brown Norway rats blastocysts.

J Genet Genomics. 2010 Jul;37(7):467-73.

  1. Wang Y, Hai T, Liu Z, Zhou S, Lv Z, Ding C, Liu L, Niu Y, Zhao X, Tong M, Wang L, Jouneau A, Zhang X, Ji W, Zhou Q.

HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):407-12

  1. Bi Y, Lv Z, Wang Y, Hai T, Huo R, Zhou Z, Zhou Q, Sha J.

WDR82, a Key Epigenetics-Related Factor, Plays a Crucial Role in Normal Early Embryonic Development in Mice.

Biol Reprod. 2011 Apr;84(4):756-64.

  1. Li W, Zhao XY, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L, Zhou Q.

iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation.

Cell Res. 2011 Mar;21(3):550-3

  1. Yu Y, Zhao C, Lv Z, Chen W, Tong M, Guo X, Wang L, Liu J, Zhou Z, Zhu H, Zhou Q,Sha J.

Microinjection manipulation resulted in the increased apoptosis of spermatocytes in testes from intracytoplasmic sperm injection (ICSI) derived mice.

PLoS One. 2011;6(7):e22172

  1. Yang Y, Zeng Y, Lv Z, Wan R, Tong M, Zhu H, Wang L, Zhou Z, Zhou Q, Sha J.

Abnormal development at early postimplantation stage in mouse embryos after preimplantation genetic diagnosis.

Anat Rec (Hoboken). 2012 Jul;295(7):1128-33.

  1. Li W, Guo XJ, Teng F, Hou XJ, Lv Z, Zhou SY, Bi Y, Wan HF, Feng CJ, Yuan Y, Zhao XY, Wang L, Sha JH, Zhou Q.

Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice.

J Mol Cell Biol. 2013 Oct;5(5):345-7.

  1. H Liu, Z Lu, A Chavez-Badiola, P Colls, S Munné, J Zhang

The in vitro development of human zygote reconstructed by pronuclear transfer

Fertility and Sterility 104 (3), e25. 2015

  1. H Liu, Z Lu, M Yang, Z Liu, Z Merhi, J Blazek, J Zhang

In vitro development of human oocytes reconstructed by sequential transfer of germinal vesicle and MII spindle

Fertility and Sterility 108 (3), e57-e58, 2017

  1. J Zhang, H Liu, S Luo, Z Lu, A Chavez-Badiola, Z Liu, M Yang, Z Merhi, …

Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease

Obstetrical & Gynecological Survey 72 (9), 542-543. 2017

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